Tumor-targeting vaccination instructs graft-vs.-tumor immune responses
نویسندگان
چکیده
Anticancer vaccines hold the potential to promote tumor eradication by immune effector cells. We have recently found dendritic cell-based vaccines to instruct graft-vs.-tumor responses following allogeneic hematopoietic stem cell transplantation and donor lymphocyte infusion. Vaccination was essential to elicit the intratumoral expression of interferon γ, promote local inflammation, and stimulate therapeutic T-cell infiltration.
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